Tissue Engineering for the Diaphragm and its Various Therapeutic Possibilities – A Systematic Review

Diaphragmatic impairments exhibit high morbidity as well mortality while current treatment options remain unsatisfactory. Tissue engineering (TE) approaches have explored the generation of an optimal biocompatible scaffold for diaphragmatic repair through tissue decellularization or de novo construction, with without addition cells. The authors conducted a systematic review on state art in (DTE) and found 24 articles eligible final synthesis. included studied decellularization-based graft (9) bioscaffold construction (9). Three studies focused vitro host-scaffold interaction synthesized, recellularized grafts (2) decellularized extracellular matrix scaffolds (1). Another three investigated evaluation tools efficacy. Among all studies, recellularization is performed both (4) generated (4). De constructed biocomposites induced pro-regenerative remodeling recovery function examined animal models. Potential therapeutic applications comprise substance defects requiring patch repair, such congenital hernia, functional diseases demanding entire organ transplant, like muscular dystrophies dysfunction after prolonged artificial respiration.